To stimulate regional economy and foster job creation, the San Jose Redevelopment Agency initially sponsored and funded the San Jose Bioscience initiative in 2000. In 2004, the Agency partnered with San Jose State University Research Foundation (SJSURF) to create a bioscience incubator and innovation center- the San Jose BioCenter. An independent management company assisted SJSURF with daily operation and management of the new facility.
Following the dissolution of the San Jose Redevelopment Agency, as of September 2012, the San Jose BioCenter began operating as an independent bioscience incubator. With guidance of real estate investor and venture capitalist, Mr. Carl E. Berg, the legacy continues. In recognition of a renewed spirit of enthusiasm, and to mark the transition, the San Jose BioCenter is now doing business as the San Jose BioCube.